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Immunization of Preterm Infants With 10-Valent Pneumococcal Conjugate Vaccine 

Pediatrics, 08/20/2011

Omenaca F et al. – Pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD–CV) was well tolerated and immunogenic in preterm infants when given as a 3–dose primary vaccination, with robust enzyme–linked immunosorbent assay antibody and OPA booster responses in the second year of life.


  • Three parallel groups of infants received 3-dose primary immunization with PHiD-CV at 2, 4, and 6 months of age and a booster dose at 16 to 18 months: preterm I; preterm II; and term.
  • Solicited symptoms and adverse events were recorded.
  • Immune responses to PHiD-CV and coadministered vaccine antigens were measured.


  • The incidence of solicited general symptoms was similar across groups, and the frequency of grade 3 general symptoms was low.
  • Incidences of redness and swelling were generally lower in preterm infants.
  • PHiD-CV was immunogenic for each of the 10 vaccine pneumococcal serotypes and for protein D, with a trend for lower postprimary geometric mean antibody concentrations and opsonophagocytic activity (OPA) titers in preterm infants for some pneumococcal serotypes.
  • Postbooster, >91.9% of subjects in each group had an OPA titer > 8 for each of the vaccine serotypes.
  • Pneumococcal antibody concentrations and OPA titers after priming and booster vaccination were comparable between the 2 preterm groups.




+1 # useless vaccineram 2012-03-27 20:46
my doctor told that globally all the countries using prevenar 13 vaccine. so, that is not good(10 valent)
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+1 # less importantsmruti 2014-03-07 00:46
prevenar13 is best and covers more bacteria than10 valent synflurics.
10 valent is very common and cheap but prevenar is best.
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+1 # Need clarificationDinesh 2012-10-10 11:40
My Ped started to gave pneumococcal vaccine to my child after 45day's, and he telling us it will be 3 does for upcoming next 2months (including current month).

I read that pneumococcal vaccine schedule is start from 2month and then goes for 4th, 6th...

Plea se adivse me what my ped doing is correct?

Is this cause my child helth?

Than ks
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+1 # good vaccinesmruti 2014-03-07 00:43
my paediatrician told Prevenar13 is a good vaccine.
and i agree its a best vaccine after doing research on internet for that and prevenar13 is much better than synflurics.
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