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HPV : Indian Scenario

 

Most common cancer in Indian women – Cervical cancer.

Incidence – 132,082 (26.7 % of worldwide incidence). worldwide approximately 500,000 women are diagnosed  every year

Mortality– 74,118 (27% of deaths worldwide).

HPV 16 & 18 in women with cervical cancer in India - 76.7%.

An increasing trend of genital wart infections in the past few years (HPV 6 & 11 are responsible for 90% of genital warts).

 

Worldwide approximately 500,000 women are diagnosed  every year

In India, by contrast, very few centres report into data sources and in some areas of Africa, incidence figures are an estimate only due to the lack of availability of cancer registries or other reporting mechanisms. Likewise, the incidence in China is reported to be low, but may be due to under-reporting.

 

Population based registry data 2002

Registry

AAR

Bangalore

17.8

Barshi

20.74

Bhopal

19.4

Chennai

26.6

Delhi

19.8

Mumbai

13.65

 

HPV Prevalence and Type-distribution in Women from India

Cytology/Histology

HPV Prevalence(%)

Invasive cervical cancer (ICC)

         94.6

High-grade squamous intraepithelial lesions (HSIL)

         86.5

low-grade squamous intraepithelial lesions (LSIL)

         65.4

Normal

         12

Bhatla N et al. A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination.

 

HPV Type-distribution in Women from India

  • HPV-16/18 positive fraction was 78.9% in women with ICC (87.7% in North and 77.2% in South India), 61.5% with HSIL, 30.8% with LSIL and 3.9% in women with normal cytology/histology.
  • HPV-16/18 vaccines will provide >75% protection against ICC. HPV 45, 33, 35 & 58 account for additional 20% of ICC

 

 

 

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