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Aluminium PDF Print E-mail

ALUMINIUM

Aluminium is one of the most abundant elements on earth and has been used in vaccines for more than 70 years.

An average daily exposure of aluminium is about 10-15 mg, most of which comes from foods. Humans and other mammals are constantly exposed to aluminium compounds and as a consequence aluminium is found in the blood of all humans and animals. Normally aluminium is excreted through the urine.

Aluminium is used in some vaccines as an adjuvant (something which helps stimulate and immune response.) The roles of aluminium adjuvants in vaccines are:

  • To bring the antigen into contact with the immune system and influence the type of immunity produced including the quality. 
  • To decrease the toxicity of certain antigens such as pertussis, diphtheria and tetanus
  • To provide solubility to some vaccine components

Were aluminium eliminated from vaccines there would be significant effects on these three issues. There are currently no obvious substitutes for aluminium as an adjuvant in vaccines. Aluminium adjuvants have an established safety record with low incidence of reported adverse events. Minor reactions occur fairly often but there have been very few serious reactions. Reactions are more likely if the injection is delivered into the subcutaneous tissue rather than deep into the muscle.

There are abundant studies concerning risk levels for ingested aluminium and minimum risk levels have been set. The deposition of aluminium following intramuscular injections had not been studied until recently because the low dose did not cause detectable changes in the plasma concentration (which is about 5micrograms per litre). However with newer techniques miniscule concentrations can now be measured. Preliminary experiments have shown that aluminium adjuvants are dissolved by citrate that is present in the space between cells and then rapidly eliminated from the body. This rapid elimination may be responsible for the excellent safety record of these adjuvants. There appears to be little potential for toxicity with vaccine level exposures to aluminium.

Aluminium administered via vaccination does not contribute significantly to the general exposure to aluminium in human and serum levels of aluminium. Based on 70 years of experience, the use of aluminium adjuvants in vaccines has proven to be safe and effective.

Last Updated on Monday, 09 February 2009 15:47
 

Comments   

 
Jagannath Chatterjee
+5 # Aluminum in Vaccines.Jagannath Chatterjee 2011-08-04 11:08
Aluminum is a metal with well documented history of neurotoxicity. Use in vaccines ranges from 125mcg to 625mcg per dose. Children may receive 4925 to 5000mcg by 18 months of age. According to the AAP, "Aluminum is now being implicated as interfering with a variety of cellular and metabolic processes in the nervous system and in other tissues." In 1997 NEJM published data that shows, "premature babies injected with aluminum build up toxic levels in blood, bones and brain…aluminum toxicity can lead to neurological damage including mental handicaps at 18 months of age." Aluminum suffers synergistic toxicity with mercury, formaldehyde (both used in vaccines) and fluoride. Aluminum can increase the toxicity of mercury 100 times (Binstock et al). Aluminum hydroxide (used in vaccines) has been clearly linked to sysmptoms associated with Dementia, Encephalopathy, Alzheimers, ALS (Lou Gehrigs Disease, Parkinson’s, CFS, macrophagic myofasciitis & Multiple Sclerosis.
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Jagannath
+3 # Study concludes: Aluminum not safe.Jagannath 2011-09-24 13:54
Curr Med Chem. 2011;18( 17):2630- 7.Aluminum vaccine adjuvants: are they safe?Tomljenovi c L, Shaw CA.Abstract: Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk
for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.PMID: 21568886 [PubMed - in process]
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pugazhendan
0 # vaccinespugazhendan 2012-09-15 10:54
why need vaccines
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Deeti geetha
0 # Aluminum in vaccinesDeeti geetha 2013-07-11 14:21
when aluminum is creating so many problems by using it in vaccines is this that much imp to use in vaccines. Is there any another option to aluminum.
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