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Vaccines are among the most sensitive drugs that are administered into the body of healthy individuals. They are sensitive to heat and freezing hence they must be stored at the correct temperature right from the time they are manufactured till they are administered. This system of storage of vaccine or the medicine is known as cold chain.

The potency of the vaccines can get affected irreversibly if the temperature is not maintained within the recommended range during the storage, transport, retailing and administering the vaccine.


The recommended temperature range for most of the vaccine is from 2°C to 8°C however the range varies for the storage and transport, even long storage and short storage temperature also varies. Few vaccines are stored at a frozen state.


Vaccine storage units must be selected carefully and used properly. A combination refrigerator/freezer unit sold for home use is acceptable for vaccine storage if the refrigerator and freezer compartments each have a separate door. However, vaccines should not be stored near the cold air outlet from the freezer to the refrigerator. This can result in different temperature zones within the refrigerator. Any refrigerator or freezer used for vaccine storage must maintain the required temperature range year-round.


Food or beverages should not be stored in vaccine storage units.


Vaccines should be stored centrally in the refrigerator or freezer, not in the door or at the bottom and away from walls to allow air to circulate.


Thermometers should be placed in a central location in the storage unit, adjacent to the vaccine. Temperatures should be read and documented twice each day, once when the office or clinic opens and once at the end of the day.


A Proper temperature charting has to be maintained by the vaccine provider and the recipient should make a habit of checking those register before purchasing the vaccines, or getting the vaccine administered from the doctor.





Last Updated on Saturday, 27 June 2009 14:00


dr cbs chouhan
+7 # photograph of refigerator with vaccine placedr cbs chouhan 2011-04-08 12:32
pse paste a photo graph of refigerator indicating vaccine name with place .this will be very useful for para medical staff &doctors regards
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MY CELL NO-9971595687
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+1 # Vaccination & Cold chain infrastructureManish 2011-07-15 13:39
Cold chain is the next buzz word we have seen typically in Indian pharmaceutical & biotech Industry
INR6 0,000 Cr.Industry is looking for corrective actions as far as cold chain distribution is concerned.
We have seen fall of few top vaccine manufacturers failed to manage cold chain distribution in Country & the same trend we have seen from years.

We might be looking for infrastructural support & special pool package for cold chain distribution
Anot her option could be to intervene in cold chain distribution via international bodies like PATH, WHO, UNICEF, GAVI(African region). We still have opportunity being not qualified as GAVI alliance can look into pooling for south Asian region
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Prasoon Rastogi
-1 # DirectorPrasoon Rastogi 2012-05-08 15:07
Dear Sir,

Plea se find reference to Our Intent Regarding Providing you Our 10000 Sq. ft facility with Cold Rooms & Logistic Solutions in Kanpur.

An infrastructure for handling Vaccines Proteins & Frozen Food Products has been developed with cold rooms, ripening chambers and frozen storage with a current capacity of 60 Tons.

We can also plan to adopt a unique distribution system of direct to Stores through specially designed vans at a specified time..

Plea se feel free to contact for any requirement. Best regards,

Farm Fresh Produce

Pras oon Rastogi

M | 8808807777
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0 # Cold Chain validationPrashant 2013-03-23 10:01
Cold Chain integrity, regulatory guidelines, its implication resulting in pharmacovigilan ce is deeply misunderstood by most people & even industry. While maintaining complete Cold Chain (end to end) is crutial to maintain vaccine stability & intigrity people in the channel still ignore relevance of having contingency plan while maintaining Cold Chain which is back-bone for any vaccine in the world.
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0 # vaccinationsantosh kumar 2014-09-21 20:00
Dear sir,
We are planning to start a retail vaccination chain in bihar. We have need some support for gathering information.
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