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Rota virus is the most common cause of severe diarrhea in infants and children

Responsible for 27,000 diarrheal deaths each year worldwide


  • Incubation period 1 – 3 days
  • Acute watery diarrhea – self-limiting, usually 2 – 7 days, possibly longer
  • Fever - first few days - can be high
  • Vomiting - first few days
  • G1 symptoms may last upto 2 – 3 weeks


Compared to other common causes of diarrhea – more severe with greater risk of dehydration & hospitalization


Rotavirus Strains

  • 7 different serogroups (A-G)
  • Only A-C cause human disease
  • Only A cause severe disease in children
  • Serotyping based on 2

            structural proteins (GVP7 & PVP4)

            – 11 possible “G” serotypes (1, 2, 3, 4, 9)

            – 11 possible “P” serotypes (4, 8)

  • Strains vary: By region and Over time
  • 5 serotypes (G1P8, G2P4, G3P8, G4P8, G9P8) cause 90% of all human infections.
  • G1P8 most prevalent globally.
  • No relation between strain and severity


Deaths due to rotavirus annually *

India : 122,270  World : 527,000 (4,75,000 – 5,80,000)

  • 29% of all deaths due to diarrhea globally.
  • 20% of all deaths in children <5 years of age from India are due to diarrhea.
  • 39.2% of all diarrhea-related hospital admissions among children aged <5 years in India (range from 35% in Mumbai to 53% in Trichy).
  • 23% of deaths due to rotavirus in world.

OPD visits >25 million

Hospitalization >2 million

*Umesh Parashar, et al Global Mortality Associated with Rotavirus among Children


Reinfection is common but symptoms will be less significant.

Transmission is Feco-oral, person-person, fomites. Clean water, hygiene unlikely to have substantial effect on virus transmission.

  • First infection usually does not lead to permanent immunity
  • Reinfection can occur at any age
  • Subsequent infections generally less severe


Most Common Types of Rotavirus Strains Found by the IRSN

G1 P[8]


G2 P[4]


G9 P[8]


G12 P[4] 6[][8]



International authorities (WHO, Institutes for Medicine, GAVI) highlight need for rotavirus vaccines

  • Disease not prevented by good sanitation & hygiene
  • Despite potential for ORS, IV fluids often needed for severe disease

Glass R et al. Lancet 2006;368:323-332




Amber Volkart
0 # age group of rota virusAmber Volkart 2011-09-10 14:39
plea se inform the age-group of rota virus infection...

than ks and regards,
ambe r
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+1 # latest straindr.g.a.manjunath 2013-06-09 21:11
Can u plz inform me the latest strain prevailing in india ?
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-1 # queryATUL SOPAN BHUJBAL 2014-07-04 22:37
please i infromation rota virus my son is 7 months complete hense canfuse rota virus medicine not given to help me?
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0 # rotavirus how many months to provide childshakeel 2015-04-22 20:12
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